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. Author manuscript; available in PMC: 2015 Jan 8.

Published in final edited form as: Chem Rev. 2013 Dec 5;114(1):233–254. doi: 10.1021/cr400161b

The adaptability of RXR and RAR LBDs to synthetic ligands. (A–B) The comparison of RXRα LBD bound to 9-cis RA and the synthetic ligand (S)- 46a,b.³¹⁷ PDB ID 1FBY and 1RDT. (C-D) The comparison of RARβ bound to 9- cis RA and TTNBP.²³⁷ PDB ID 1XDK and 4DM6. (E-F) The comparison of RARβ bound to all-trans RA and BMS184394.⁷⁶ PDB ID 2LBD and 1FCX.

The adaptability of RXR and RAR LBDs to synthetic ligands. (A–B) The comparison of RXRα LBD bound to 9-cis RA and the synthetic ligand (S)- 46a,b.³¹⁷ PDB ID 1FBY and 1RDT. (C-D) The comparison of RARβ bound to 9- cis RA and TTNBP.²³⁷ PDB ID 1XDK and 4DM6. (E-F) The comparison of RARβ bound to all-trans RA and BMS184394.⁷⁶ PDB ID 2LBD and 1FCX.