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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Curr Opin Immunol. 2013 Oct 11;0:1–6. doi: 10.1016/j.coi.2013.09.005

Figure 1.

Figure 1

The four human CD1 isoforms adopt unique three-dimensional structures that dictate the repertoire of lipid ligands they present. Shown are cartoon representations of CD1a, CD1b, CD1c and CD1d with approximated tunnel structures. As discussed in the text, each isoform presents unique lipid types (small boxes colored as the CD1 molecule), however the overall presented endogenous lipidome is highly overlapping (large box, colored yellow). CD1b, in particular, is reliant upon highly hydrophobic scaffolding lipids such as diacylglycerols (DAGs) and deoxyceramides (DOCs) in order to present much of its endogenous lipids, these are shown at the interface between shared and unique CD1b lipid antigens.