Table 1.
Patient characteristics
| High pAKT | Low pAKT | All patients | |
|---|---|---|---|
| Number treated | 10 | 5 | 15 |
| Gender | 9 men:1 woman | 2 men; 3 women | 11 men; 4 women |
| Median age (range) | 60 (22-78) | 70 (55-74) | 68 (22-78) |
| Median ECOG performance status (range) | 0 (0-1) | 1 (0-2) | 0 (0-2) |
| Stage at treatment | |||
| IIIc | 0 | 1 | 1 |
| IVA | 1 | 0 | 1 |
| IVB | 2 | 0 | 2 |
| IVC | 7 | 4 | 11 |
| Pre-treatment LDH levels | |||
| Normal | 5 | 3 | 8 |
| Elevated | 5 | 2 | 7 |
| Previous systemic treatment | |||
| None | 1 | 0 | 1 |
| Chemotherapy | 7 | 5 | 12 |
| Immunotherapy | 4 | 1 | 5 |
| Ipilimumab | 2 | 0 | 2 |
| BRAF-directed therapy | 1 | 1 | 2 |
| # of prior therapies/patient | |||
| 0 | 1 | 0 | 1 |
| 1 | 4 | 2 | 6 |
| 2 | 1 | 2 | 3 |
| 3 | 1 | 1 | 2 |
| >3 | 3 | 0 | 3 |