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Adverse events of grade 2 or greater possibly or probably attributable to selumetininb.
| No. of patients | |||
|---|---|---|---|
| Toxicity | Grade 2 | Grade 3 | Grade 4 |
| Acneiform rash | 3 | 2 | |
| ↑ AST | 2 | ||
| ↑ ALT | 2 | 1 | |
| ↑ Alk phosphatase | 2 | 1 | |
| Anemia | 2 | ||
| ↑ glucose | 2 | ||
| Fatigue | 2 | ||
| Diarrhea | 2 | ||
| ↓ lymphocyte count | 3 | ||
| Edema | 2 | ||
| ↓ albumin | 1 | ||
| ↑ bilirubin | 2 | 1 | |
| Dyspnea | 1 | ||
| ↓ phosphate | 1 | ||
| LV dysfunction | 2 | ||
| RV dysfunction | 1 | ||
| Vomiting | 1 | ||
| Valvular heart disease | 1 | ||
| Chest wall pain | 1 | ||
| Heart failure | 1 | ||
| ↓ magnesium | 1 | ||
| Pleural effusion | 1 | ||
