Table 2.
List of consistently up- and downregulated transcripts (cut off 1.4 fold change)
| Gene | Chromosome | Function | Protein levels | Link to cancer? | |
|---|---|---|---|---|---|
| 1 |
PLAUR |
19 |
Plasminogen activator, urokinase receptor |
4/5 |
Ovarian and colorectal cancer |
| 2 |
RAB27B |
18 |
Secretory GTPase |
4/4 |
Breast cancer |
| 3 |
P4HA2 |
5 |
Procollagen-proline |
4/6 |
Metastasis |
| 4 |
FRY |
13 |
Regulator of actin cytoskeleton |
0/3 |
|
| 5 |
BDKRB1 |
14 |
Bradykinine receptor |
NA |
Breast and lung cancer |
| 6 |
HOXB5 |
17 |
Transcription factor |
NA |
Leukemia, ovarian carcinoma and others |
| 7 |
GDF15 |
19 |
Growth differentiation factor |
1/2 |
Ovarian and prostate cancer |
| 8 |
OASL |
12 |
2'-5'-oligoadenylate synthetase-like |
NA |
|
| 9 |
SERPINE2 |
2 |
Serpine protease inhibitor |
4/4 |
Metastasis |
| 10 |
IFI44 |
1 |
Interferon-induced protein 44 |
NA |
|
| 11 |
AMDHD1 |
12 |
Protein with amidohydrolase domain |
NA |
|
| 12 |
TMEM171 |
5 |
Transmembrane protein 171 |
NA |
|
| 13 |
GLRX |
5 |
Glutaredoxin |
4/4 |
Pancreatic cancer |
| 14 |
TMEM169 |
2 |
Transmembrane protein 169 |
NA |
|
| 15 |
DMBT1 |
10 |
Membrane glycoprotein |
NA |
Multiple cancers |
| 16 |
COL13A1 |
10 |
Collagen type XIII, alpha1 |
1/1 |
|
| 17 |
SH2D1B |
1 |
Signal transduction control |
NA |
|
| 18 |
MIA |
|
Melanoma inhibitory activity |
NA |
Neuronal tumors |
| |
|
|
|
|
|
| 1 |
XYLB |
3 |
Xylulokinase homologue |
NA |
|
| 2 |
LOXL3 |
2 |
Lysyl oxidase homologue |
NA |
|
| 3 |
MYB/NFIB fusion |
6 |
Myb – NFIB fusion |
NA |
|
| 4 |
EEPD |
7 |
Endonuclease/exonuclease/phosphatase domain containing |
NA |
|
| 5 | ARHGEF39 | 9 | Rho guanine nucleotide exchange factor 39 | NA |
The column “Protein levels” shows how often corresponding changes of the protein levels were identified by Stingele et al. [15] (number of cell lines with altered protein expression/number of cell lines where the protein was quantified; NA – proteomics data not available). The rows 1-18 show upregulated genes; the rows 1- 5 (below) show downregulated genes.