Table 3.
Peptides Shared Between Influenza H1N1 HA and Guidance Proteins Are Present in B- and/or T-Cell Epitopes
| IEDB IDa | Epitope Sequenceb,c | Immune Recognition Context | Influenza A H1N1 Virus Strain |
|---|---|---|---|
| 798 | ADYEELREQLSSVSS | T | New Caledonia/20/1999 |
| 6801 | CPKYVRSAKL | T | Puerto Rico/8/1934 |
| 26959 | ILAIYSTVASSL | T | California/04/2009 |
| 28063 | IPSIQSRGL | T | Puerto Rico/8/1934 |
| 29691 | IYSTVASSLVL | T | Puerto Rico/8/1934 |
| 35415 | LEDSHNGKL | T | Denver/1957 |
| 61460 | SSVSSFERF | T | camel/Mongolia/1982 |
| 79792 | DTIIFEANGNLIA | T | New Caledonia/20/1999 |
| 79809 | ELLVLLENERTLD | T | New Caledonia/20/1999 |
| 79864 | IIFEANGNLIAPW | T | New Caledonia/20/1999 |
| 80034 | SSLPFQNVHPVTI | T | New Caledonia/20/1999 |
| 80050 | TGLRNIPSIQSRG | T | New Caledonia/20/1999 |
| 113324 | DGFLDIWTYNAELLV | T | New Caledonia/20/1999 |
| 113375 | EQLSSVSSFERFE | T | New Caledonia/20/1999 |
| 113595 | KYVRSAKLRMVT | T | New Caledonia/20/1999 |
| 125913 | ELLVLLENERTLDYHDS | T | California/04/2009 |
| 126340 | ITFEATGNLVVPRYAFA | T | California/04/2009 |
| 128403 | DDGFLDIWTYNAELLVL | T | New Caledonia/20/1999 |
| 129178 | KVKSQLKNNAKEIGNG | T | New Caledonia/20/1999 |
| 129221 | LEKNVTVTHSVNLLEDS | T | New Caledonia/20/1999 |
| 129319 | LRMVTGLRNIPSIQSRG | T | New Caledonia/20/1999 |
| 129320 | LRNIPSIQSRGLFGAIA | T | New Caledonia/20/1999 |
| 129890 | SFWMCSNGSLQCRICI | T | New Caledonia/20/1999 |
| 129938 | SLGAISFWMCSNGSLQ | T | New Caledonia/20/1999 |
| 130394 | YQILAIYSTVASSLVLL | T | New Caledonia/20/1999 |
| 144630 | ELLVLLENERTLDYHDSNVK | T | California/04/2009 |
| 144688 | IDYEELREQLSSVSSFERFE | T | California/04/2009 |
| 144696 | IYQILAIYSTVASSLVLVVSLGA | T | California/04/2009 |
| 144732 | NLYEKVRSQLKNNAKEIGNG | T | California/04/2009 |
| 144810 | VLEKNVTVTHSVNLLEDK | T | California/04/2009 |
| 144813 | VTHSVNLLEDKHNGKLCK | T | California/04/2009 |
| 150978 | EKNVTVTHSVNLLED | B | California/04/2009 |
| 150998 | ILGNPECESLSTASS | B | California/04/2009 |
| 150999 | IPSIQSRGLFGAIAG | B | California/04/2009 |
| 151026 | LREQLSSVSSFERFE | B | California/04/2009 |
| 151036 | NLLEDKHNGKLCKLR | B | California/04/2009 |
| 151056 | SQLKNNAKEIGNGCF | B | California/04/2009 |
| 151063 | TFEATGNLVVPRYAF | B | California/04/2009 |
| 151064 | TPKGAINTSLPFQNI | B | California/04/2009 |
| 151075 | YNAELLVLLENERTL | B | California/04/2009 |
| 151076 | YPGDFIDYEELREQL | B | California/04/2009 |
| 152919 | QLSSVSSFERFEIFPKTSSW | T | California/04/2009 |
Note: IEDB was searched for influenza A HA epitopes that had produced humoral or cellular immune responses in the human host. The search generated 537 epitopes; of which, 120 refer to H1N1 strains, and 42 correspond to H1N1 HA-derived sequences containing peptide fragments (in italics) shared between HA and guidance proteins (see table 2).
aFor epitope further details and references, refer to www.immuneepitope.org.92
baa sequences given in 1-letter code.
cPeptide fragments shared between HA and guidance proteins are given in italics.