Fig. 1.

Mean differences (SD) on biomarkers between FEP and controls (univariate analysis). (a) NFκB activity in PBMC nuclear extracts from FEP patients (n = 53) and controls (n = 35); (b) Western blot analysis of proinflammatory proteins iNOS (patients n = 91, controls, n = 88); (c) COX-2 in PBMC cytosolic extracts from FEP patients (n = 90) and controls (n = 88); and (d) plasma levels of nitrites (NO₂⁻; patients n = 50, controls, n = 61), (e) proinflammatory prostaglandin E₂ (patients n = 111, controls, n = 104), (f) thiobarbituric acid reactive substances (patients n = 105, controls, n = 104), and (g) homocysteine from FEP patients (n = 71) and controls (n = 41). AU, arbitrary units. Two-tailed nonparametric Mann-Whitney U test was used. ° represents an atypical value and * an extreme value.