Table 2.
Minimum Effective Doses of Second-Generation Antipsychotic Drugs and Dose Equivalents
| Drug | Minimum Effective Dose | OLA 1 mg Equivalent |
RIS 1 mg Equivalent |
HAL 1 mg Equivalent |
CPZ 100 mg Equivalent |
|---|---|---|---|---|---|
| Amisulpride | − | − | − | − | − |
| Aripiprazole | 10 | 1.33 (1) | 5 (2.5) | 2.5 (2.2) | 4 (3.6) |
| Asenapine | 10 | 1.33 (1) | 5 (2.5) | 2.5 (2.2) | 4 (3.6) |
| Clozapine | 300? | 40 (30) | 150 (75) | 75 (67) | 120 (107) |
| Haloperidol | 4 (4.5) | 0.53 (0.45) | 2 (1.13) | 1 | 1.6 |
| Iloperidone | 8a (12) | 1.07a (1.2) | 4a (3) | 2a (2.7) | 3.2a (4.3) |
| Lurasidone | 40 | 5,33 (4) | 20 (10) | 10 (8.9) | 16 (14.2) |
| Olanzapine | 7.5 (10) | 1 | 3.75 (2.5) | 1.88 (2.2) | 3 (3.6) |
| Paliperidone | 3 (6) | 0.4 (0.6) | 1.5 (1.5) | 0.75 (1.3) | 1.2 (2.1) |
| Quetiapine | 150 (250) | 20 (25) | 75 (62.5) | 37.5 (55.6) | 60 (88.9) |
| Risperidone | 2 (4) | 0.27 (0.4) | 1 | 0.5 (0.9) | 0.8 (1.4) |
| Sertindole | 12 (16) | 1.60 (1.6) | 6 (4) | 3 (3.6) | 4.8 (5.7) |
| Ziprasidone | 40 (80) | 5.33 (8) | 20 (20) | 10 (17.8) | 16 (28.4) |
| Zotepine | − | − | − | − | − |
Note: We present the minimum effective doses and the doses in milligrams that are equivalent to 1 mg/d olanzapine (OLA), 1 mg/d risperidone (RIS), 1 mg/d haloperidol (HAL), and 100 mg/d chlorpromazine (CPZ). Numbers in parentheses are the results of the sensitivity analysis (2 positive trials). The results of the sensitivity analysis are only shown if they deviated from the primary analysis. (−): means that no recommendation could be made. (?): the result is very questionable because it is based on a single small study comparing clozapine 300 mg/d with 100 mg/d, but not with placebo.
aExcluding patients with schizoaffective disorder, the minimum effective iloperidone dose based on the primary criterion is 12 mg/d; the resulting equivalence doses (mg/d) are: olanzapine 1.6, risperidone 6, haloperidol 3, and chlorpromazine 4.8.