Table 1.
Intraday and interday precision and accuracy of linifanib in rat plasma
|
Nominal concentration (ng/mL) |
Run |
|
Rat plasma |
|
|---|---|---|---|---|
| Mean ± SD | Precision (% CV) | Accuracy (%) | ||
|
Intraday variation (six replicate at each concentration)
| ||||
| 0.45 |
1 |
0.48 ± 0.05 |
10.4 |
107.0 |
| |
2 |
0.47 ± 0.05 |
10.6 |
104.4 |
| |
3 |
0.49 ± 0.05 |
10.2 |
108.9 |
| 1.28 |
1 |
1.35 ± 0.14 |
10.4 |
105.3 |
| |
2 |
1.38 ± 0.14 |
10.1 |
105.0 |
| |
3 |
1.35 ± 0.08 |
5.9 |
105.6 |
| 42.5 |
1 |
44.5 ± 3.28 |
7.4 |
104.6 |
| |
2 |
39.7 ± 3.58 |
9.0 |
93.5 |
| |
3 |
40.2 ± 1.56 |
3.9 |
94.6 |
| 425 |
1 |
397 ± 36.4 |
9.2 |
93.5 |
| |
2 |
387 ± 12.2 |
3.2 |
90.9 |
| |
3 |
398 ± 13.5 |
3.4 |
93.9 |
|
Interday variation (18 replicates at each concentration)
| ||||
| 0.45 |
|
0.48 ± 0.05 |
10.4 |
106.8 |
| 1.28 |
|
1.36 ± 0.09 |
6.6 |
106.3 |
| 42.5 |
|
41.48 ± 3.53 |
8.5 |
97.6 |
| 425 | 394 ± 22.79 | 5.8 | 92.8 | |