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. Author manuscript; available in PMC: 2014 Feb 23.
Published in final edited form as: Biochim Biophys Acta. 2011 Jul 7;1819(0):238–246. doi: 10.1016/j.bbagrm.2011.06.013

Figure 1.

Figure 1

Nucleosome assembly of new H3-H4. (A) There are two major nucleosome assembly pathways: replication coupled (RC) nucleosome assembly and replication independent (RI) nucleosome assembly. Histone chaperone Asf1 binds a H3-H4 dimer, which will be transferred to histone chaperones that are involved in RC or RI nucleosome assembly. (B) Models of formation of histone (H3-H4)2 tetramers, the first building block of a nucleosome. Two H3-H4 dimers from Asf1 can be transferred to a histone chaperone to form one (H3-H4)2 tetramer on a monomeric or dimeric form of the histone chaperon. Alternatively, a H3-H4 heterodimer will be transferred from Asf1 to another histone chaperone, which will deposit two H3-H4 dimers sequentially onto DNA for formation of a (H3-H4)2 tetramer.