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. Author manuscript; available in PMC: 2014 Feb 23.
Published in final edited form as: Biochim Biophys Acta. 2011 Jul 7;1819(0):238–246. doi: 10.1016/j.bbagrm.2011.06.013

Figure 2.

Figure 2

Roles for post-translational modifications on newly-synthesized histones in nucleosome assembly. Described are the enzymes, post-translational modification (PTM) and function associated with known modifications observed on newly-synthesized H3-H4. (A) Acetylation of the H3 N-terminal tail by Gcn5 and Rtt109 and H3K56 (within the H3 core domain) by Rtt109 regulates the interaction between histone chaperones (like CAF-1) and H3-H4. (B) H3K9me, catalyzed by SetDB1 (in complex with CAF-1 and HP1alpha), serves as a substrate for Suv39, and thereby contributing to the epigenetic inheritance of the H3K9me3 mark. (C) Hat1 catalyzes H4K5,12Ac, which may help regulate histone import from the cytoplasm into the nucleus.