Table 2.
IL12A, IL12RB, and STAT4 SNPs in PBC patients and healthy subjects.
| Gene | db SNP | Allele | GWAS cohort | Replication cohort | Combined cohort | ||||
|---|---|---|---|---|---|---|---|---|---|
| minor/major | patients (%) | patients (%) | patients (%) | Controls (%) | P | OR | 95% CI | ||
| (n = 302) | (n = 93) | (n = 395) | (n = 458) | ||||||
| IL12A | rs574808 | C/T | 17.2 | 18.3 | 17.5 | 18.1 | 0.75 | ||
| IL12RB | rs3790567 | A/G | 26.8 | 22.0 | 25.7 | 22.9 | 0.18 | ||
| STAT4 | rs7574865 | T/G | 40.6 | 46.8 | 41.9 | 33.5 | 4.0 × 10−4 | 1.43 | 1.17–1.74 |
IL12: interleukin 12; STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval.