Table 4.
STAT4 haplotypes in PBC patients and healthy subjects.
| Block | Haplotype | SNPs | Patients (%) | Controls (%) | P | OR | 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|
| (n* = 790) | (n* = 916) | ||||||||
| A | rs7594501 | rs16833239 | rs11889341 | ||||||
| 1 | G | C | C | 46.4 | 50.0 | 0.222 | |||
| 2 | G | C | T | 40.3 | 32.2 | 3.5 × 10−3 | 1.43 | 1.12–1.81 | |
| 3 | A | T | C | 11.9 | 15.9 | 0.045 | |||
|
| |||||||||
| B | rs7574865 | rs8179673 | rs10181656 | ||||||
| 4 | G | A | C | 53.9 | 65.4 | 5.0 × 10−5 | 0.62 | 0.49–0.78 | |
| 5 | T | G | G | 43.3 | 33.6 | 6.0 × 10−4 | 1.51 | 1.19–1.91 | |
| 6 | G | A | G | 2.1 | 0.0 | 3.0 × 10−4 | |||
STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval; n*: values for n* indicate two times the number of individuals since each person carries two haplotypes.