Table 5.
Correlations between STAT4 SNPs and autoantibody positivity.
| db SNP | Allele | ANA+ (%) | ANA− (%) | P | OR | 95% CI | AMA+ (%) | AMA− (%) | P | Cenp+ (%) | Cenp− (%) | P | gp210+ (%) | gp210− (%) | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| minor/major | (n* = 271) | (n* = 124) | (n* = 369) | (n* = 26) | (n* = 119) | (n* = 243) | (n* = 80) | (n* = 180) | |||||||
| rs10168266 | A/G | 35.6 | 33.1 | 0.50 | 34.2 | 42.3 | 0.24 | 36.1 | 35.3 | 0.83 | 35.0 | 32.5 | 0.58 | ||
| rs7594501 | A/G | 11.5 | 14.9 | 0.18 | 12.9 | 7.7 | 0.27 | 13.0 | 12.6 | 0.87 | 11.9 | 12.8 | 0.77 | ||
| rs16833239 | T/C | 11.6 | 15.3 | 0.15 | 13.1 | 7.7 | 0.26 | 12.6 | 13.4 | 0.77 | 13.1 | 13.1 | 0.98 | ||
| rs11889341 | T/C | 41.3 | 34.7 | 0.076 | 38.8 | 46.2 | 0.29 | 59.7 | 59.7 | 1.00 | 39.4 | 37.2 | 0.64 | ||
| rs7574865 | T/G | 44.5 | 36.7 | 0.040 | 1.38 | 1.01–1.88 | 41.6 | 48.1 | 0.36 | 42.4 | 43.6 | 0.76 | 43.1 | 38.3 | 0.30 |
| rs8179673 | G/A | 44.8 | 36.7 | 0.032 | 1.40 | 1.03–1.91 | 41.9 | 48.1 | 0.38 | 42.9 | 43.8 | 0.81 | 43.1 | 38.6 | 0.33 |
| rs10181656 | G/C | 46.1 | 37.9 | 0.031 | 1.40 | 1.03–1.91 | 43.1 | 50.0 | 0.33 | 45.0 | 44.4 | 0.90 | 43.1 | 38.6 | 0.33 |
| rs6752770 | G/A | 15.4 | 14.1 | 0.63 | 15.3 | 11.5 | 0.47 | 13.4 | 14.7 | 0.64 | 15.0 | 15.8 | 0.81 |
STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval; AMA: anti-mitochondrial antibody; ANA: anti-nuclear antibody; Cenp: anti-centromere antibody; gp210: gp210 antibody; n*: values for n* indicate two times the number of individuals since each person carries two haplotypes.