Table 6.
Correlations between STAT4 haplotypes and autoantibody positivity.
| Block | Haplotype | SNPs | ANA+ (%) | ANA− (%) | P | OR | 95% CI | AM+ (%) | AMA− (%) | P | Cenp+ (%) | Cenp− (%) | P | gp210+ (%) | gp210− (%) | P | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n* = 542) | (n* = 248) | (n* = 738) | (n* = 52) | (n* = 238) | (n* = 486) | (n* = 160) | ||||||||||||
| A | rs7594501 | rs16833239 | rs11889341 | |||||||||||||||
| 1 | G | C | C | 46.7 | 49.6 | 0.45 | 47.7 | 46.2 | 0.83 | 46.6 | 46.1 | 0.89 | 47.5 | 49.2 | 0.73 | |||
| 2 | G | C | T | 41.3 | 34.7 | 0.076 | 38.8 | 46.2 | 0.29 | 40.3 | 40.3 | 1.00 | 39.4 | 37.2 | 0.64 | |||
| 3 | A | T | C | 11.1 | 14.5 | 0.17 | 12.5 | 7.7 | 0.31 | 12.6 | 12.3 | 0.92 | 11.9 | 12.2 | 0.91 | |||
|
| ||||||||||||||||||
| B | rs7574865 | rs8179673 | rs10181656 | 0.0 | ||||||||||||||
| 4 | G | A | C | 53.7 | 61.7 | 0.035 | 0.72 | 0.53–0.98 | 56.8 | 48.1 | 0.22 | 54.6 | 55.3 | 0.85 | 56.9 | 61.4 | 0.33 | |
| 5 | T | G | G | 44.3 | 36.3 | 0.035 | 1.40 | 1.02–1.90 | 41.5 | 46.2 | 0.51 | 42.0 | 43.4 | 0.72 | 43.1 | 38.3 | 0.30 | |
| 6 | G | A | G | 1.5 | 1.6 | 0.88 | 1.4 | 3.8 | 0.16 | 2.5 | 0.8 | 0.066 | 0.0 | 0.0 | — | |||
STAT4: signal transducer activator transcription 4; PBC: primary biliary cirrhosis; SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval; AMA: anti-mitochondrial antibody; ANA: anti-nuclear antibody; Cenp: anti-centromere antibody; gp210: gp210 antibody; n*: values for n* indicate two times the number of individuals since each person carries two haplotypes.