Table 3.
HapE × diet interaction on carotid IMT by multivariate GEE analysis in American Indians (total N=3402)
| Variables | HapE × n-3 PUFA
|
HapE × n-6 PUFA
|
||
|---|---|---|---|---|
| Coefficient | Multivariate-P* | Coefficient | Multivariate-P* | |
| HapE | 0.99 | 0.54 | 0.99 | 0.40 |
| n-3 fatty acids | 1.05 | 0.02 | 1.00 | 0.62 |
| n-6 fatty acids | 1.00 | 0.59 | 1.00 | 0.96 |
| n-3 × HapE | 1.05 | 0.018 | - | - |
| n-6 × HapE | - | - | 1.01 | 0.04 |
| Age | 1.01 | <0.0001 | 1.01 | <0.0001 |
| Female sex | 0.95 | <0.0001 | 0.95 | <0.0001 |
| Study center | 1.01 | 0.17 | 1.01 | 0.17 |
| BMI | 1.00 | 0.0005 | 1.00 | <0.0001 |
| SBP | 1.00 | <0.0001 | 1.00 | <0.0001 |
| Smoking | 1.02 | 0.02 | 1.02 | 0.02 |
| Alcohol use | 0.98 | 0.02 | 0.97 | 0.01 |
| Total cholesterol | 1.00 | 0.15 | 1.00 | 0.18 |
| Triglyceride | 1.00 | 0.08 | 1.00 | 0.07 |
| eGFR | 1.00 | 0.29 | 1.01 | 0.25 |
| Daily energy intake | 1.00 | 0.59 | 1.00 | 0.50 |
| Diabetes | 1.06 | <0.0001 | 1.06 | <0.0001 |
*
Adjusted for age, sex, study center, BMI, systolic blood pressure, diabetes, smoking, alcohol consumption, total cholesterol, triglyceride, eGFR, saturated fat and total daily energy intake. The interactions of HapE with n-3 or n-6 fatty acids were adjusted for one another.