Table 1.
Patient characteristics
| Variable | All, n = 101 (%) | PC Group, n = 47 (%) | EC Group, n = 54 (%) | p Value |
|---|---|---|---|---|
| Age, yrs, mean ± SD | 61.4 ± 11.5 | 61.3 ± 9.9 | 61.6 ± 12.9 | 0.89 |
| Women | 41 (40.6) | 18 (38.3) | 23 (42.6) | 0.66 |
| Time since AF Dx (yrs), median (IQR) | 3.82 (1.33–7.38) | 4.36 (1.33–7.29) | 3.47 (1.27–7.83) | 0.96 |
| Duration current AF (mo), median (IQR) | 1.86 (0.47–6.03) | 1.87 (0.45–5.77) | 1.37 (0.47–7.35) | 0.82 |
| Dofetilide dose (μg BID) | ||||
| 125 | 3 (3.0) | 1 (2.1) | 2 (3.7) | 0.71 |
| 250 | 45 (44.5) | 21 (44.7) | 24 (44.4) | |
| 500 | 53 (52.5) | 25 (53.1) | 28 (51.9) | |
| QTc, BL (ms), mean ± SD | 442 ± 33.4 | 439.4 ± 40.0 | 443.8 ± 26.7 | 0.53 |
| HR, BL (beats/min), mean ± SD | 92.9 ± 22.4 | 95.0 ± 24.2 | 91.1 ± 21.0 | 0.39 |
| Previous class IC use | 22 (21.8) | 14 (29.8) | 8 (14.8) | 0.07 |
| Previous amiodarone | 23 (22.8) | 11 (23.4) | 12 (22.2) | 0.89 |
| Previous AF ablation | 10 (9.9) | 7 (14.9) | 3 (5.6) | 0.12 |
| LA size | ||||
| Normal | 13 (12.9) | 6 (12.8) | 7 (13.0) | 0.35 |
| Mildly enlarged | 20 (19.8) | 16 (34.0) | 14 (25.9) | |
| Moderately enlarged | 20 (19.8) | 11 (23.4) | 9 (16.7) | |
| Severely enlarged | 20 (19.8) | 6 (12.8) | 14 (26.0) | |
| Not available | 18 (17.8) | 8 (17.0) | 10 (18.5) | |
| Diabetes mellitus | 9 (8.9) | 6 (12.8) | 3 (5.6) | 0.24 |
| Hypertension | 64 (63.4) | 28 (59.6) | 36 (66.7) | 0.46 |
| Hyperlipidemia | 30 (29.7) | 15 (31.9) | 15 (27.8) | 0.65 |
| Heart failure | 20 (19.8) | 8 (17.0) | 8 (17.0) | 0.51 |
| Obesity | 17 (16.8) | 8 (17.0) | 8 (17.0) | 0.96 |
Chi-square tests were used to test for differences between categorical variables. t Tests were used to test for differences between normally distributed continuous variables (HR, QTc, and age). Wilcoxon tests were used to test for differences between continuous variables that were not normally distributed (time since AF diagnosis and duration of current AF). LA sizes were defined by American Society of Echocardiography criteria.14
BID = twice daily; BL = baseline; Dx = diagnosis; IQR = interquartile range; LA = left atrium.