Systemic AMPH (1 mg/kg i.p.) administration increased M1 GABA (C), dopamine (D), NE (E) and 5-HT (F). M1 perfusion of NBQX (10 μM; white triangles) blocked AMPH-induced release of GABA, dopamine, NE and 5-HT. M1 perfusion of MK-801 (10 μM) increased dopamine (D), while attenuating AMPH-stimulated dopamine and NE. Antagonist perfusion is represented by the black bar. Data are expressed as percent baseline ± SEM.
*p<0.05, AMPH alone group significantly different from NBQX + AMPH group
**p<0.01, AMPH alone group significantly different from NBQX + AMPH group
#p<0.05, AMPH alone group significantly different from MK801 + AMPH group
##p<0.01, AMPH alone group significantly different from MK801 + AMPH group