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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Curr Allergy Asthma Rep. 2014 Feb;14(2):402. doi: 10.1007/s11882-013-0402-8

Figure 1. The bone marrow niche.

Figure 1

Long-lived, dormant hematopoietic stem cells (HSCs) associate with osteoblasts to sustain quiescence in the endosteal niche and serve as the primitive cell “reservoir” within the bone marrow (BM). HSCs that reside within the perivascular niche associate with Nestin-positive mesenchymal stem cells (MSCs) and CXCL12-abundant reticular (CAR) cells that secrete CXCL12 to influence HSC maintenance and activity by either retaining cells within the BM or allowing cells into circulation, which may be impacted by the balance and regulation of CXCL12/CXCR4 and S1P/S1P1R.