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Summary of different types of network motifs in miRNA mediated gene regulatory networks. (A) Summary of miRNA biogenesis and mechanism of action. (B) Positive and (C) negative feedback loops, with a miRNA and a transcription factor. (D) Single input module with miRNA regulating three target nodes. The extent of regulation can differ between different targets. Feed-forward loops (E) Incoherent and (F) coherent feedforward loops with a miRNA regulating the target-T2.
