Table 3.
Potential for clinical decision support
| Event | Statin | Calcineurin inhibitor | a | b | c | d | AOR025 |
|---|---|---|---|---|---|---|---|
| Rhabdomyolysis | Nystatin | Tacrolimus | 21 | 2324 | 1357 | 562 296 | 0.67 |
| Atorvastatin | 20 | 1267 | 1358 | 563 353 | 0.96 | ||
| Nystatin | Cyclosporine | 32 | 1407 | 1346 | 563 213 | 1.78 | |
| Atorvastatin | 37 | 1331 | 1341 | 563 289 | 2.26 |
This table shows AOR025 scores for the association of rhabdomyolysis with the combination of calcineurin inhibitors like tacrolimus or cyclosporine A, and statins. It appears that tacrolimus is relatively safe and this agrees with in vivo experiments.
AOR, adjusted OR.