Table 3.

Performance of CASTLE with robust PC, CASTLE with PC and LASSO for each SOC-specific ADR using both chemical and biological features

MedDRA SOC-specific ADR	CASTLE with robust PC		CASTLE with PC		LASSO
	No of features	F1 score	No of features	F1 score	No of features	F1 score
C0014130; Endocrine system diseases	21	0.83	35	0.83	147	0.79
C0015397; Disorder of eye	14	0.81	31	0.79	104	0.77
C0009450; Communicable diseases	11	0.93	22	0.92	0	0.92
C0027651; Neoplasms	14	0.74	34	0.71	110	0.73
C0004936; Mental disorders	18	0.90	38	0.85	106	0.88
C0027765; Nervous system disorder	11	0.97	21	0.98	0	0.97
C0018799; Heart diseases	19	0.88	30	0.85	173	0.87
C0263660; Musculoskeletal and connective tissue disorders	10	0.91	41	0.90	88	0.88
C0017178; Gastrointestinal diseases	17	0.96	28	0.96	25	0.95
C0178298; Skin and subcutaneous tissue disorders	12	0.97	23	0.97	0	0.98
C0042075; Urologic diseases	17	0.85	34	0.85	50	0.83
C0042373; Vascular diseases	11	0.94	35	0.94	0	0.94

ADR, adverse drug reaction; CASTLE, causality analysis model based on structure learning; LASSO, Least Absolute Shrinkage and Selection Operator; MedDRA, Medical dictionary for regulatory activities; PC, parents-and-children; SOC, system organ class.