Table 4.

Set of biological factors identified as having a causal relationship with SOC-specific ADRs and supported by evidence in OMIM

Gene	SOC-specific ADR	OMIM
ARMD1	Neoplasms	Colorectal cancer, susceptibility to
BAAT	Vascular diseases	Hypercholanemia, familial
BCR	Disorder of eye	Retinal dystrophy, early-onset severe retinitis pigmentosa
BRCA1	Endocrine system diseases	Pancreatic cancer
	Gastrointestinal diseases	Pancreatic cancer
COX1	Gastrointestinal diseases	Peroxisomal acyl-CoA oxidase deficiency
DIH1	Musculoskeletal and connective tissue disorders	Hernia, congenital diaphragmatic
MAL	Mental disorders	Mental retardation, autosomal dominant
	Nervous system disorder	Hereditary motor and sensory neuropathy
	Skin and subcutaneous tissue disorders	Digital arthropathy-brachydactyly, familial
NEP	Mental disorders	Mental retardation, autosomal dominant
RIT1	Nervous system disorder	Cavernous malformations of central nervous system and retina
RLF	Mental disorders	Cold-induced sweating syndrome
SERPINC1	Endocrine system diseases	Thrombophilia due to antithrombin III deficiency
SERPINH2	Heart diseases	Osteogenesis imperfecta, type X

ADR, adverse drug reaction; OMIM, Online Mendelian Inheritance in Man; SOC, system organ class.