Table 1. In vitro anti-leishmanial activity of OlPC against Leishmania spp. promastigotes.
| Leishmania spp. and strain | IC50 (95% CI), μM |
|---|---|
| Old World strains | |
| L. donovani archibaldi 2211 (MHOM/SD/91/D1783; LEM 2211) | 8.0 (6.2–10.5) |
| L. donovani donovani sudanese 1S2D (MHOM/SD/62/1S-CL2D) | 4.0 (2.7–5.7) |
| L. donovani infantum LV9 (MHOM/ET/67/HU3) | 3.0 (1.6–6.4)* |
| L. major LV39 (MRHO/Sv/59/P) | 1.1 (0.9–1.3) |
| New World strains | |
| L. mexicana amazonensis LV78 (MPRP/BR/72/M1845) | 5.7 (3.2–12.8)* |
| L. guyanensis (MHOM/SR/87/TRUUS4) | 3.0 (2.3–3.9) |
| L. mexicana (MNYC/BZ/62/M379) | 2.1 (1.3–3.7) |
| L. panamensis (MHOM/87/CO/UA140) | 2.7 (2.2–3.4) |
| L. tarantolae (TarIIWT) | 7.8 (6.6–9.2) |
*Confidence intervals were conservatively defined by concentrations resulting in ≤5% and ≥95% reduction in parasite density, as they could not be reliably calculated by the software. Data shown are the mean of the three independent experiments made in duplicates.