Table 1.

Z-matrix for hierarchical logistic regression model for the flavonoid-gene interaction in association with breast cancer risk in LIBCSP using an indicator-term approach

No.	Indicator Variable1	Gene Function	Flavonoid Intake Low = 0 High = 1	↑ROS2	↓Phase 2 activity	↓DNA repair activity	↓Methyl group formation
1	mnsod_flav_ind1	Beneficial	0	0	0	0	0
2	mnsod_flav_ind2	Deleterious	1	1	0	0	0
3	mnsod_flav_ind3	Beneficial	1	0	0	0	0
4	mpo_flav_ind1	Beneficial	0	0	0	0	0
5	mpo_flav_ind2	Deleterious	1	1	0	0	0
6	mpo_flav_ind3	Beneficial	1	0	0	0	0
7	cat_flav_ind1	Beneficial	0	0	0	0	0
8	cat_flav_ind2	Deleterious	1	1	0	0	0
9	cat_flav_ind3	Beneficial	1	0	0	0	0
10	gsta1_flav_ind1	Beneficial	0	0	0	0	0
11	gsta1_flav_ind2	Deleterious	1	1	1	0	0
12	gsta1_flav_ind3	Beneficial	1	0	0	0	0
13	gstm1_flav_ind1	Beneficial	0	0	0	0	0
14	gstm1_flav_ind2	Deleterious	1	0	1	0	0
15	gstm1_flav_ind3	Beneficial	1	0	0	0	0
16	gstp1_flav_ind1	Beneficial	0	0	0	0	0
17	gstp1_flav_ind2	Deleterious	1	0	1	0	0
18	gstp1_flav_ind3	Beneficial	1	0	0	0	0
19	gstt1_flav_ind1	Beneficial	0	0	0	0	0
20	gstt1_flav_ind2	Deleterious	1	0	1	0	0
21	gstt1_flav_ind3	Beneficial	1	0	0	0	0
22	ercc1_flav_ind1	Beneficial	0	0	0	0	0
23	ercc1_flav_ind2	Deleterious	1	0	0	1	0
24	ercc1_flav_ind3	Beneficial	1	0	0	0	0
25	xpa_flav_ind1	Beneficial	0	0	0	0	0
26	xpa_flav_ind2	Deleterious	1	0	0	1	0
27	xpa_flav_ind3	Beneficial	1	0	0	0	0
28	xpd312_flav_ind1	Beneficial	0	0	0	0	0
29	xpd312_flav_ind2	Deleterious	1	0	0	1	0
30	xpd312_flav_ind3	Beneficial	1	0	0	0	0
31	mthfr677_flav_ind1	Beneficial	0	0	0	0	0
32	mthfr677_flav_ind2	Deleterious	1	0	0	0	1
33	mthfr677_flav_ind3	Beneficial	1	0	0	0	0
34	mthfr1298_flav_ind1	Beneficial	0	0	0	0	0
35	mthfr1298_flav_ind2	Deleterious	1	0	0	0	1
36	mthfr1298_flav_ind3	Beneficial	1	0	0	0	0
37	comt_flav_ind1	Beneficial	0	0	0	0	0
38	comt_flav_ind2	Deleterious	1	−1	0	0	1
39	comt_flav_ind3	Beneficial	1	0	0	0	0

¹Referent group for the single-referent analysis is “Deleterious” gene function, and “Low” flavonoid intake.

²ROS = reactive oxygen species