. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Cancer Causes Control. 2013 Nov 27;25(2):215–226. doi: 10.1007/s10552-013-0324-8

Table 2.

Random effects odds ratios (OR), 95% confidence intervals (95% CI), and confidence limit ratios (CLR) from conventional models (Single GxE, Multivariate) and hierarchical logistic regression models for flavonoid-gene interaction in association with breast cancer risk in the LIBCSP (N=1778)

Gene Variant rs#	Variant Function	Flavonoid Intake¹	Case	Control	Single G×E			Multivariate			Hierarchical

					OR²	95% CI	CLR³	OR²	95% CI	CLR³	OR²	95% CI	CLR³
MnSOD	Deleterious	Low	112	105	1.00			1.00			1.00
rs1799725	Beneficial	Low	334	347	1.09	0.80, 1.48	1.85	1.07	0.78, 1.47	1.87	1.06	0.80, 1.41	1.77
	Deleterious	High	112	107	0.98	0.67, 1.43	2.13	1.19	0.47, 3.01	6.37	0.93	0.54, 1.63	3.03
	Beneficial	High	345	316	0.95	0.70, 1.30	1.86	1.18	0.48, 2.90	6.01	0.93	0.54, 1.58	2.92
MPO	Deleterious	Low	259	284	1.00			1.00			1.00
rs2333227	Beneficial	Low	187	168	0.82	0.63, 1.08	1.71	0.83	0.63, 1.09	1.73	0.85	0.66, 1.09	1.66
	Deleterious	High	276	256	0.84	0.65, 1.07	1.63	0.91	0.39, 2.11	5.40	0.93	0.54, 1.61	2.98
	Beneficial	High	181	167	0.82	0.63, 1.08	1.73	0.91	0.39, 2.14	5.55	0.93	0.55, 1.59	2.92
CAT	Deleterious	Low	160	177	1.00			1.00			1.00
rs1001179	Beneficial	Low	286	275	0.86	0.66, 1.13	1.72	0.87	0.66, 1.15	1.74	0.89	0.69, 1.15	1.67
	Deleterious	High	162	164	0.89	0.66, 1.22	1.85	1.13	0.47, 2.71	5.82	1.00	0.58, 1.73	2.99
	Beneficial	High	295	259	0.78	0.59, 1.03	1.73	0.96	0.40, 2.31	5.77	0.87	0.51, 1.48	2.91
GSTA1	Deleterious	Low	274	310	1.00			1.00			1.00
rs3957356	Beneficial	Low	172	142	0.76	0.57, 1.00	1.74	0.78	0.59, 1.04	1.76	0.81	0.62, 1.05	1.69
	Deleterious	High	305	273	0.79	0.63, 1.00	1.60	0.81	0.35, 1.87	5.31	0.89	0.51, 1.56	3.04
	Beneficial	High	152	150	0.86	0.65, 1.14	1.76	0.86	0.37, 2.01	5.43	0.95	0.55, 1.63	2.94
GSTM1	Deleterious	Low	189	225	1.00			1.00			1.00
gene deletion	Beneficial	Low	257	227	0.72	0.55, 0.94	1.70	0.73	0.56, 0.96	1.72	0.76	0.59, 0.98	1.65
	Deleterious	High	229	206	0.73	0.55, 0.96	1.73	0.77	0.32, 1.82	5.68	0.89	0.51, 1.55	3.02
	Beneficial	High	228	217	0.78	0.59, 1.02	1.73	0.81	0.34, 1.93	5.69	0.94	0.55, 1.61	2.93
GSTP1	Deleterious	Low	245	218	1.00			1.00			1.00
rs1695	Beneficial	Low	201	234	1.31	1.01, 1.71	1.70	1.30	0.99, 1.70	1.71	1.25	0.98, 1.61	1.65
	Deleterious	High	221	217	1.09	0.83, 1.42	1.70	1.60	0.69, 3.76	5.48	0.97	0.56, 1.68	3.01
	Beneficial	High	236	206	0.97	0.74, 1.26	1.70	1.43	0.60, 3.37	5.58	0.87	0.51, 1.49	2.94
GSTT1	Deleterious	Low	98	104	1.00			1.00			1.00
gene deletion	Beneficial	Low	348	348	0.96	0.70, 1.31	1.88	0.97	0.70, 1.33	1.90	0.97	0.73, 1.30	1.79
	Deleterious	High	101	86	0.82	0.55, 1.23	2.23	0.96	0.38, 2.47	6.55	0.88	0.50, 1.54	3.09
	Beneficial	High	356	337	0.88	0.64, 1.21	1.88	1.06	0.43, 2.64	6.14	0.96	0.56, 1.65	2.94
ERCC1	Deleterious	Low	205	215	1.00			1.00			1.00
rs3212986	Beneficial	Low	241	237	0.93	0.72, 1.22	1.69	0.97	0.72, 1.29	1.79	0.97	0.74, 1.26	1.70
	Deleterious	High	200	206	0.96	0.73, 1.27	1.69	1.17	0.47, 2.90	6.17	1.10	0.63, 1.93	3.07
	Beneficial	High	257	217	0.79	0.61, 1.04	1.70	1.07	0.44, 2.57	6.17	0.99	0.57, 1.72	3.00
XPA	Deleterious	Low	387	404	1.00			1.00			1.00
rs1800975	Beneficial	Low	59	48	0.79	0.53, 1.19	2.26	0.75	0.50, 1.14	2.30	0.82	0.57, 1.16	2.04
	Deleterious	High	395	381	0.91	0.74, 1.11	1.50	1.20	0.61, 2.37	3.90	1.24	0.69, 2.24	3.24
	Beneficial	High	62	42	0.64	0.42, 0.97	2.31	0.83	0.38, 1.80	4.74	0.88	0.50, 1.54	3.06
XPD	Deleterious	Low	244	271	1.00			1.00			1.00
rs1799793	Beneficial	Low	202	181	0.80	0.61, 1.04	1.71	0.78	0.58, 1.04	1.80	0.81	0.62, 1.06	1.71
	Deleterious	High	242	254	0.93	0.72, 1.19	1.65	1.12	0.46, 2.69	5.80	1.19	0.68, 2.09	3.07
	Beneficial	High	215	169	0.69	0.53, 0.90	1.71	0.86	0.36, 2.03	5.65	0.92	0.53, 1.59	3.00
MTHFR	Deleterious	Low	273	279	1.00			1.00			1.00
C677T	Beneficial	Low	173	173	0.97	0.74, 1.28	1.72	1.01	0.76, 1.33	1.75	1.00	0.77, 1.30	1.68
rs1801133	Deleterious	High	271	264	0.94	0.74, 1.19	1.62	1.23	0.54, 2.78	5.10	0.97	0.55, 1.70	3.10
	Beneficial	High	186	159	0.82	0.62, 1.08	1.73	1.11	0.48, 2.57	5.36	0.88	0.51, 1.51	2.96
MTHFR	Deleterious	Low	224	221	1.00			1.00			1.00
A1298C	Beneficial	Low	222	231	1.05	0.81, 1.37	1.69	1.11	0.84, 1.46	1.73	1.09	0.84, 1.40	1.66
rs1801131	Deleterious	High	234	191	0.81	0.62, 1.06	1.72	0.96	0.40, 2.26	5.59	0.82	0.47, 1.45	3.09
	Beneficial	High	223	232	1.03	0.79, 1.35	1.70	1.22	0.52, 2.90	5.62	1.03	0.60, 1.78	2.96
COMT	Deleterious	Low	113	128	1.00			1.00			1.00
rs4680	Beneficial	Low	333	324	0.87	0.65, 1.17	1.81	0.84	0.62, 1.14	1.84	0.87	0.66, 1.14	1.74
	Deleterious	High	119	117	0.85	0.59, 1.23	2.07	1.01	0.41, 2.50	6.12	0.96	0.38, 2.45	6.48
	Beneficial	High	338	306	0.80	0.59, 1.07	1.82	0.93	0.38, 2.25	5.88	0.88	0.49, 1.58	3.20

Low flavonoid intake ≤ 150 mg/day, high flavonoid intake > 150 mg/day.

All models adjusted for age and total energy intake.

CLR = Upper 95% Confidence Limit / Lower 95% Confidence Limit. Calculated using 95% CI estimates.