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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Cancer Causes Control. 2013 Nov 27;25(2):215–226. doi: 10.1007/s10552-013-0324-8

Table 2.

Random effects odds ratios (OR), 95% confidence intervals (95% CI), and confidence limit ratios (CLR) from conventional models (Single GxE, Multivariate) and hierarchical logistic regression models for flavonoid-gene interaction in association with breast cancer risk in the LIBCSP (N=1778)

Gene
Variant
rs#
Variant
Function
Flavonoid
Intake1
Case Control Single G×E Multivariate Hierarchical



OR2 95% CI CLR3 OR2 95% CI CLR3 OR2 95% CI CLR3
MnSOD Deleterious Low 112 105 1.00 1.00 1.00
rs1799725 Beneficial Low 334 347 1.09 0.80, 1.48 1.85 1.07 0.78, 1.47 1.87 1.06 0.80, 1.41 1.77
Deleterious High 112 107 0.98 0.67, 1.43 2.13 1.19 0.47, 3.01 6.37 0.93 0.54, 1.63 3.03
Beneficial High 345 316 0.95 0.70, 1.30 1.86 1.18 0.48, 2.90 6.01 0.93 0.54, 1.58 2.92
MPO Deleterious Low 259 284 1.00 1.00 1.00
rs2333227 Beneficial Low 187 168 0.82 0.63, 1.08 1.71 0.83 0.63, 1.09 1.73 0.85 0.66, 1.09 1.66
Deleterious High 276 256 0.84 0.65, 1.07 1.63 0.91 0.39, 2.11 5.40 0.93 0.54, 1.61 2.98
Beneficial High 181 167 0.82 0.63, 1.08 1.73 0.91 0.39, 2.14 5.55 0.93 0.55, 1.59 2.92
CAT Deleterious Low 160 177 1.00 1.00 1.00
rs1001179 Beneficial Low 286 275 0.86 0.66, 1.13 1.72 0.87 0.66, 1.15 1.74 0.89 0.69, 1.15 1.67
Deleterious High 162 164 0.89 0.66, 1.22 1.85 1.13 0.47, 2.71 5.82 1.00 0.58, 1.73 2.99
Beneficial High 295 259 0.78 0.59, 1.03 1.73 0.96 0.40, 2.31 5.77 0.87 0.51, 1.48 2.91
GSTA1 Deleterious Low 274 310 1.00 1.00 1.00
rs3957356 Beneficial Low 172 142 0.76 0.57, 1.00 1.74 0.78 0.59, 1.04 1.76 0.81 0.62, 1.05 1.69
Deleterious High 305 273 0.79 0.63, 1.00 1.60 0.81 0.35, 1.87 5.31 0.89 0.51, 1.56 3.04
Beneficial High 152 150 0.86 0.65, 1.14 1.76 0.86 0.37, 2.01 5.43 0.95 0.55, 1.63 2.94
GSTM1 Deleterious Low 189 225 1.00 1.00 1.00
gene deletion Beneficial Low 257 227 0.72 0.55, 0.94 1.70 0.73 0.56, 0.96 1.72 0.76 0.59, 0.98 1.65
Deleterious High 229 206 0.73 0.55, 0.96 1.73 0.77 0.32, 1.82 5.68 0.89 0.51, 1.55 3.02
Beneficial High 228 217 0.78 0.59, 1.02 1.73 0.81 0.34, 1.93 5.69 0.94 0.55, 1.61 2.93
GSTP1 Deleterious Low 245 218 1.00 1.00 1.00
rs1695 Beneficial Low 201 234 1.31 1.01, 1.71 1.70 1.30 0.99, 1.70 1.71 1.25 0.98, 1.61 1.65
Deleterious High 221 217 1.09 0.83, 1.42 1.70 1.60 0.69, 3.76 5.48 0.97 0.56, 1.68 3.01
Beneficial High 236 206 0.97 0.74, 1.26 1.70 1.43 0.60, 3.37 5.58 0.87 0.51, 1.49 2.94
GSTT1 Deleterious Low 98 104 1.00 1.00 1.00
gene deletion Beneficial Low 348 348 0.96 0.70, 1.31 1.88 0.97 0.70, 1.33 1.90 0.97 0.73, 1.30 1.79
Deleterious High 101 86 0.82 0.55, 1.23 2.23 0.96 0.38, 2.47 6.55 0.88 0.50, 1.54 3.09
Beneficial High 356 337 0.88 0.64, 1.21 1.88 1.06 0.43, 2.64 6.14 0.96 0.56, 1.65 2.94
ERCC1 Deleterious Low 205 215 1.00 1.00 1.00
rs3212986 Beneficial Low 241 237 0.93 0.72, 1.22 1.69 0.97 0.72, 1.29 1.79 0.97 0.74, 1.26 1.70
Deleterious High 200 206 0.96 0.73, 1.27 1.69 1.17 0.47, 2.90 6.17 1.10 0.63, 1.93 3.07
Beneficial High 257 217 0.79 0.61, 1.04 1.70 1.07 0.44, 2.57 6.17 0.99 0.57, 1.72 3.00
XPA Deleterious Low 387 404 1.00 1.00 1.00
rs1800975 Beneficial Low 59 48 0.79 0.53, 1.19 2.26 0.75 0.50, 1.14 2.30 0.82 0.57, 1.16 2.04
Deleterious High 395 381 0.91 0.74, 1.11 1.50 1.20 0.61, 2.37 3.90 1.24 0.69, 2.24 3.24
Beneficial High 62 42 0.64 0.42, 0.97 2.31 0.83 0.38, 1.80 4.74 0.88 0.50, 1.54 3.06
XPD Deleterious Low 244 271 1.00 1.00 1.00
rs1799793 Beneficial Low 202 181 0.80 0.61, 1.04 1.71 0.78 0.58, 1.04 1.80 0.81 0.62, 1.06 1.71
Deleterious High 242 254 0.93 0.72, 1.19 1.65 1.12 0.46, 2.69 5.80 1.19 0.68, 2.09 3.07
Beneficial High 215 169 0.69 0.53, 0.90 1.71 0.86 0.36, 2.03 5.65 0.92 0.53, 1.59 3.00
MTHFR Deleterious Low 273 279 1.00 1.00 1.00
C677T Beneficial Low 173 173 0.97 0.74, 1.28 1.72 1.01 0.76, 1.33 1.75 1.00 0.77, 1.30 1.68
rs1801133 Deleterious High 271 264 0.94 0.74, 1.19 1.62 1.23 0.54, 2.78 5.10 0.97 0.55, 1.70 3.10
Beneficial High 186 159 0.82 0.62, 1.08 1.73 1.11 0.48, 2.57 5.36 0.88 0.51, 1.51 2.96
MTHFR Deleterious Low 224 221 1.00 1.00 1.00
A1298C Beneficial Low 222 231 1.05 0.81, 1.37 1.69 1.11 0.84, 1.46 1.73 1.09 0.84, 1.40 1.66
rs1801131 Deleterious High 234 191 0.81 0.62, 1.06 1.72 0.96 0.40, 2.26 5.59 0.82 0.47, 1.45 3.09
Beneficial High 223 232 1.03 0.79, 1.35 1.70 1.22 0.52, 2.90 5.62 1.03 0.60, 1.78 2.96
COMT Deleterious Low 113 128 1.00 1.00 1.00
rs4680 Beneficial Low 333 324 0.87 0.65, 1.17 1.81 0.84 0.62, 1.14 1.84 0.87 0.66, 1.14 1.74
Deleterious High 119 117 0.85 0.59, 1.23 2.07 1.01 0.41, 2.50 6.12 0.96 0.38, 2.45 6.48
Beneficial High 338 306 0.80 0.59, 1.07 1.82 0.93 0.38, 2.25 5.88 0.88 0.49, 1.58 3.20
1

Low flavonoid intake ≤ 150 mg/day, high flavonoid intake > 150 mg/day.

2

All models adjusted for age and total energy intake.

3

CLR = Upper 95% Confidence Limit / Lower 95% Confidence Limit. Calculated using 95% CI estimates.