Table 3.
Gene pathways | OR1 | 95% CI2 |
---|---|---|
Increased oxidative stress | 1.00 | 0.62, 1.63 |
Reduced Phase 2 Metabolism | 0.97 | 0.58, 1.65 |
Reduced DNA repair capability | 1.27 | 0.70, 2.29 |
Reduced methyl group formation | 0.983 | 0.53, 1.82 |
Note: Odds ratios and 95% confidence intervals estimated using fixed effects coefficients from hierarchical model: logit (p|X, W, Z) = α + XZπ + Xδ + Wγ
OR = exp[π]
95% CI = exp[π ± 1.96*SE(π)]
Example interpretation for fixed effects OR for reduced methyl group formation: “The average effect of deleterious versus beneficial gene, controlling for average flavonoid intake in the reduced methyl group formation pathway, and adjusted for the three other pathways, results in a 2% reduced risk for breast cancer.”