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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Cancer Causes Control. 2013 Nov 27;25(2):215–226. doi: 10.1007/s10552-013-0324-8

Table 3.

Fixed effects odds ratios (OR) and 95% confidence intervals (95% CI) from hierarchical logistic regression models for flavonoid-gene interaction in association with breast cancer risk in the LIBCSP (N=1778)

Gene pathways OR1 95% CI2
Increased oxidative stress 1.00 0.62, 1.63
Reduced Phase 2 Metabolism 0.97 0.58, 1.65
Reduced DNA repair capability 1.27 0.70, 2.29
Reduced methyl group formation 0.983 0.53, 1.82

Note: Odds ratios and 95% confidence intervals estimated using fixed effects coefficients from hierarchical model: logit (p|X, W, Z) = α + XZπ + Xδ + Wγ

1

OR = exp[π]

2

95% CI = exp[π ± 1.96*SE(π)]

3

Example interpretation for fixed effects OR for reduced methyl group formation: “The average effect of deleterious versus beneficial gene, controlling for average flavonoid intake in the reduced methyl group formation pathway, and adjusted for the three other pathways, results in a 2% reduced risk for breast cancer.”