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A) Illustration of cardiac muscle sarcomere with interdigitating myosin-thick and actin-thin filaments. MyBP-C is localized to the C-zones. B) Schematic diagram of MyBP-C’s Ig-like (oval) and fibronectin-like (rectangle) domains structure, functionally significant 29 kDa region, M-domain with 4 phosphorylation sites and cardiac specific C5 insert. Domains involved with sarcomeric protein binding are indicated.
