Effect of genotype on activation during the TIME condition. In a comparison
between A1+ and A1- genotypes, only A1+ subjects exhibited significant
activation, exclusively in the bilateral basal ganglia and right dorsolateral
prefrontal cortex. When dividing this contrast into sub and supra-second
duration intervals, A1+ subjects exhibited basal ganglia activation for both
ranges, but only right prefrontal activation for supra-second intervals. A1-
subjects did not exhibit any differences at either range. All contrasts were
masked by the TIME vs. COLOR regression contrast and are significant at
p<0.001, uncorrected. Right
panels display mean parameter estimates (β values) for A1+ and A1- groups
in left caudate and SFG for sub and supra-second intervals, error bars indicate
standard error.