Table 1. Demographics and basic characteristics of the primary and replication cohorts.
Primary cohort | AZ cohort | PA cohort | P-value | |
---|---|---|---|---|
| ||||
Sample size | 690 | 276 | 113 | - |
| ||||
Geographic location | Central PA | Scottsdale, AZ | Central PA | - |
| ||||
% Female | 73% | 68% | 74% | 0·272 |
| ||||
% Caucasian | 97% | 89% | 96% | <0·0001 |
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Age (years): <40 (%) | 14% | 13% | 15% | |
40–49 | 30% | 34% | 32% | 0·119 |
50–59 | 37% | 41% | 36% | |
60+ | 19% | 11% | 17% | |
| ||||
Pre-surgery BMI (kg/m2), mean (SD) | 49·4 (8·3) | 48·4 (8·3) | 49·5 (9·3) | 0·200 |
| ||||
HbA1c (%): <6·5 | 38% | 28% | 43% | |
6·5–6·9 | 16% | 18% | 14% | 0·056 |
7·0–8·9 | 30% | 39% | 34% | |
9·0+ | 15% | 15% | 9% | |
| ||||
Metformin use | 78% | 74% | 83% | 0·103 |
| ||||
Sulfonylureas use | 31% | 33% | 32% | 0·851 |
| ||||
Other ISA | 32% | 41% | 20% | 0·0004 |
| ||||
Insulin use | 36% | 28% | 38% | 0·032 |
| ||||
Serum Insulin (μU/mL): >=30 | 72% | 71% | 71% | 0·868 |
| ||||
DiaRem score: 0–2 | 27% | 18% | 27% | |
3–7 | 30% | 43% | 32% | |
8–12 | 10% | 14% | 11% | 0·0031 |
13–17 | 24% | 17% | 22% | |
18–22 | 8% | 7% | 8% |