Table 4. DiaRem score weights with corresponding elements and their hazard ratios (HR) used for weighting each variable contributing to the DiaRem score.
The hazard ratios represent failure to remit T2D (partial + complete). The hazard ratio for each DiaRem score (or penalty) was as follows: Score=1: Age 40–50 (HR=1·08); Score=2: Age 50–59 (HR=1·31), HbA1c 6·5%–6·9% (HR=1·46); Score=3: Age 60+ (HR=1·78), ISA+Sulf (HR=2·07); Score=4: HbA1c 7·0–8·9 (HR=2·51); Score=6: HbA1c 9+ (HR=3·35); Score=10: Insulin meds (HR=5·90). The Full Cox regression model was used to estimate the hazard ratios using all T2D patients (N=690).
| Failure of T2D remission
| ||||
|---|---|---|---|---|
| Hazard ratio | 95% Confidence interval | P-value | ||
|
| ||||
| Pre-operative Insulin medication | Yes | 5·90 | [4·41, 7·90] | <0·0001 |
| No | Reference | - | - | |
|
| ||||
| Age (years) | <40 | Reference | - | |
| 40–50 | 1·08 | [0·82, 1·41] | 0·602 | |
| 50–60 | 1·31 | [1·00, 1·73] | 0·053 | |
| 60+ | 1·78 | [1·27, 2·49] | 0·0009 | |
|
| ||||
| Pre-operative HbA1c (%) | <6·5 | Reference | - | - |
| 6·5–6·9 | 1·46 | [1·12, 1·89] | 0·0045 | |
| 7·0–8·9 | 2·51 | [1·96, 3·23] | <0·0001 | |
| 9·0+ | 3·35 | [2·24, 5·03] | <0·0001 | |
|
| ||||
| Pre-operative diabetes medications | Other* | Reference | - | - |
| ISA+Sulf‡ | 2·07 | [1·50, 2·84] | <0·0001 | |
*
Other: none, Metformin (Met) only, Sulfonylurea (Sulf) only, insulin sensitizing agent other than metformin (ISA), Met+Sulf, Met+ISA.
‡
ISA+Sulf: insulin sensitizing agent other than metformin + sulfonylurea therapy combined.