Table 3.
Author (reference) | Sample | Results |
---|---|---|
Ridker et al. [62] | 543 apparently healthy men | Serum CRP levels predict MI and CVD: The quartile with the highest CRP levels had a greater risk of MI (RR: 2.9; P < 0.001) and CVD (RR: 1.9; P < 0.02) than the lowest quartile. |
| ||
Ridker et al. [71] | 366 apparently healthy women (122 developed a cardiovascular event) | Serum CRP levels of patients who had a cardiovascular event were higher than control patients (P = 0.0001). Patients with the highest levels had a greater risk of developing MI or CVD (RR: 7.3; P = 0.0001). |
| ||
Ridker et al. [72] | 27939 apparently healthy women | CRP is a more powerful predictor of cardiovascular events than LDL-C. The RR for a first cardiovascular event was, according to CRP quintiles: 1.4–1.6–2.0–2.3 (P < 0.001). |
| ||
Cesari et al. [73] | 2225 participants aged 70–79 years without previously diagnosed cardiovascular disease | Inflammatory markers are predictors of cardiovascular events in elderly patients. CRP was associated with CHF (RR: 1.48; IC: 1.23–1.78). |
| ||
Ridker et al. [74] | 24558 initially healthy women (≥45 years of age) | 2 new algorithms were developed for the calculation of global cardiovascular risk, reclassifying a great part of women with average risk according to conventional scoring systems. |
Ridker et al. [75] | 10724 initially healthy women (≥50 years of age) | A new prediction model was developed for the calculation of global cardiovascular risk, including CRP and family history of cardiovascular events. Over 20.2% of the population was reclassified from the original distribution of conventional scoring systems. |
| ||
Kaptoge et al. [76] | 160309 subjects without history of vascular disease (54 prospective studies) | The association of CRP with vascular disease depends on other inflammatory markers and classic risk factors. After multiple adjustments, the RR for coronary disease was (1.23; IC: 1.07–1.42), for CVD (1.32; IC: 1.18–1.49), and for vascular cause mortality (1.34; IC: 1.18–1.52). |
| ||
Maiorana et al. [77] | 37 patients with 3 or more cardiovascular risk factors | 10 patients had LDL-C >100 mg/dL, fibrinogen >350 mg/dL, and CRP >2.6 mg/L; 6 of these patients presented a positive ischemia by exercise testing and coronary disease. |
CRP: C-reactive protein; MI: myocardial infarction; CVD: cerebrovascular disease; RR: relative risk; LDL-C: low-density lipoproteins; CHF: congestive heart failure; CI: confidence interval.