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. Author manuscript; available in PMC: 2014 Jul 19.
Published in final edited form as: ACS Synth Biol. 2013 Jan 17;2(7):384–396. doi: 10.1021/sb3001003

Figure 3.

Figure 3

HPLC profiles of mycelial extracts of S. avermitilis wild-type strain and its aveR deletion mutant. Solid and dotted lines indicate the production profiles of the wild-type strain and aveR mutant, respectively. Each strain was cultured in avermectin production medium for 168 hr at 28°C. Methanol extract from mycelium was directly applied to ODS-HPLC (HyperSil 3 μm; 4.6 φ × 100 mm) and developed with acetonitrile/methanol/water (65:10:25) at a flow rate of 0.6 mL/min.