Table 1.

Estimated breast cancer odds ratios (ORs) for haplotypes in the XRCC2 gene in SBCS

Haplotypes*	Case frequency (%)	Control frequency (%)	OR (95% CI)
Block1†
1-1-2-1-1	987.98 (43.68)	1024.45 (44.62)	1
1-1-1-1-2	524.75 (23.2)	510.97 (22.25)	1.07 (0.92–1.24)
1-1-1-1-1	393.56 (17.4)	368.08 (16.03)	1.12 (0.94–1.33)
1-2-1-1-1	178.07 (7.87)	203.09 (8.85)	0.9 (0.72–1.13)
2-1-1-1-1	85.94 (3.8)	93.79 (4.09)	0.94 (0.69–1.3)
1-1-1-2-1	80.14 (3.54)	80.29 (3.5)	1.03 (0.75–1.42)
rare haplotypes	11.57 (0.51)	15.33 (0.67)	0.77 (0.34–1.77)
Block2‡
1-1-1-1-1-1-2	959.74 (42.43)	1004.07 (43.73)	1
1-1-1-2-1-2-1	506.51 (22.39)	501.74 (21.85)	1.05 (0.90–1.23)
1-1-1-1-2-2-1	230.88 (10.21)	221.96 (9.67)	1.10 (0.89–1.35)
2-1-1-1-1-2-1	175.95 (7.78)	197.57 (8.60)	0.91 (0.73–1.13)
1-2-2-1-1-1-1	102.96 (4.55)	108.17 (4.71)	0.99 (0.73–1.33)
1-1-2-1-1-1-1	95.57 (4.23)	96.37 (4.20)	1.06 (0.76-1.47)
1-1-1-1-1-2-1	85.98 (3.8)	99.69 (4.34)	0.89 (0.64–1.23)
rare haplotypes	104.42 (4.61)	66.43 (2.89)	1.68 (1.21–2.32)
	20.24 (0.89)	4.56 (0.20)	6.50 (1.88–22.48)
	84.17 (3.72)	61.87 (2.69)	1.37 (0.96–1.97)

^*1 represents the common allele and 2 the minor allele. “Rare haplotypes” indicates those with frequency below 1%.

^†the order of SNPs in block 1 are rs3218556, rs3218536, rs3218534, rs3218501, and rs3218499.

^‡The order of SNPs in block 2 are rs3218455, rs3111465, rs3094406, rs3218408, rs3218400, rs2106776, and rs3218374.

^§the bracket indicates the subdivision of the rare haplotypes into 1112112 and the rest.