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. Author manuscript; available in PMC: 2015 Jan 31.
Published in final edited form as: FEBS Lett. 2013 Dec 25;588(3):472–481. doi: 10.1016/j.febslet.2013.12.011

Figure 1. Rac1-inhibition decreases oxidative stress in SHSY-5Y cells.

Figure 1

Rotenone increases overall intracellular (A) and extracellular (B) ROS, which is attenuated by inhibition of Nox activity (gp91 ds) or Rac1 (Rac1(−))Rotenone enhances Nox-specific ROS production, which is prevented by inhibition of Nox activity with gp91 ds or a Rac1 inhibitor (C), and catalase (D). Rotenone induces oxidation of cellular glutathione, which is prevented by inhibition of either Nox activity or Rac1(E). Data are representative of three replicates. *p < 0.05 and **p<0.01.