Skip to main content
. Author manuscript; available in PMC: 2015 Jan 31.
Published in final edited form as: FEBS Lett. 2013 Dec 25;588(3):472–481. doi: 10.1016/j.febslet.2013.12.011

Figure 3. Rac1-inhibition attenuates reactive nitrogen species (RNS) production in SHSY-5Y cells.

Figure 3

Rotenone increases RNS production in SHSY-5Y cells, which is mitigated by inhibition of Nox activity with gp91 ds or a Rac1 inhibitor (A). Rotenone stimulated mitochondrial ROS production, which is not inhibited by a Rac1 inhibitor (B). Production of mitochondrial ROS by antimysin-A does not induce calcium influx in SHSY-5y cells (C&D)Dashed line in D indicates normalized value of calcium influx prior addition of extracellular Mn2+ Data are representative of three replicates. *p < 0.05 and **p<0.01.