Skip to main content
. Author manuscript; available in PMC: 2015 Jan 31.
Published in final edited form as: FEBS Lett. 2013 Dec 25;588(3):472–481. doi: 10.1016/j.febslet.2013.12.011

Figure 5. Rac1 plays a major role in Nox-induced misfolded protein aggregation and apoptotic cell death in SHSY-5Y cells.

Figure 5

Rotenone induces misfolded protein aggregation in the insoluble (A&C) and soluble (B&C) protein fractions as measured by accumulation of ubiquitinated proteins. Rotenone also increases cleaved PARP-1, indicating increased apoptosis (D&E). Both misfolded protein aggregation and apoptosis was prevented by inhibition of Rac1. Data are representative of three independent experiments. *p < 0.05 and **p<0.01.