Fig. 4. Overexpression of TIMP-1 upregulates cyclinD1 and downregulates p21^CIP1 and p27^KIP1, but this effect can be abolished by LY294002. (A) CyclinD1, are highly upregulated while p21^CIP1 and p27^KIP1 are downer-gulated in the T group compared to Con group, but these effect of TIMP-1 are blocked by LY294002(T+LY294002 group). (B) Densitometry analysis of the intensities of these protein bands is presented as their ratios to the actin levels. The band intensity of the control group is arbitrarily set as 1.0, *p < 0.05 versus the Con group.