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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Exp Hematol. 2013 Oct 29;42(2):101–113.e5. doi: 10.1016/j.exphem.2013.10.005

Figure 1. ITD/NPMc+ mice have a shortened survival and a clinical phenotype consistent with acute leukemia.

Figure 1

A) Kaplan-Meier survival curve demonstrating a shortened overall survival for mice with both a Flt3/ITD mutation and a NPMc+ mutation (ITD/NPMc+, N=87) compared to mice of other genotypes (wild type controls (wt/wt, N=18), Flt3/ITD alone (ITD, N=50), NPMc+ alone (NPMc+, N=30)). These mice become moribund prior to death and have clinical characteristic of acute leukemia including: B) splenomegaly, C) leukocytosis, D) anemia, and E) thrombocytopenia. For B–E, number of mice included: wt, N=20; ITD/NPMc+, N=40; ITD, N=15; NPMc+, N=8.

n/s, not statistically significant.