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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Exp Hematol. 2013 Oct 29;42(2):101–113.e5. doi: 10.1016/j.exphem.2013.10.005

Figure 3. ITD/NPMc+ mice develop myeloid and lymphoid leukemias.

Figure 3

A) Flow cytometry plots demonstrating the characteristic phenotype of wt mice (row 1), ITD mice with myeloproliferative neoplasm (row 2), NPMc+ mice with myeloproliferation (row 3) and each of the 4 most common types of acute leukemia diagnosed in ITD/NPMc+ mice (rows 4–7). All the leukemic mice also have a paucity of normal maturing erythrocytes as demonstrated by decreased Ter119+ cells in the BM and maturing B lymphocytes indicated by decreased B220+/CD19+ cell in the BM. B) Disease distribution of the 40 fully characterized ITD/NPMc+ mice.