Table 1.
Demographics and baseline characteristics.
| Extent of disease | ||
|---|---|---|
| Non-obstructive CAD | Obstructive CAD | |
| Total number of patients | 3550 | 33,551 |
| Age, median (25th, 75th percentiles) | 62.0 (51.0, 69.4) | 65.7 (57.5, 73.0) |
| Female sex | 1974/3550 (55.6) | 9849/33,551 (29.4) |
| Weight, kg | ||
| No. | 3548 | 33,543 |
| Median (25th, 75th percentiles) | 76.7 (66.0, 90.0) | 79.3 (70.0, 90.0) |
| White | 2938/3549 (82.8) | 29,730/33,540 (88.6) |
| Current smoker | 876/3536 (24.8) | 9348/33,479 (27.9) |
| Diabetes | 536/3550 (15.1) | 8834/33,545 (26.3) |
| Prior CABG | 0/3549 (0.0) | 5335/33,542 (15.9) |
| Prior CHF | 261/3541 (7.4) | 3011/33,513 (9.0) |
| Prior MI | 513/3549 (14.5) | 10,659/33,503 (31.8) |
| Prior PCI | 367/3550 (10.3) | 6603/33,536 (19.7) |
| Prior PVD | 118/3550 (3.3) | 3416/33,544 (10.2) |
| Heart rate, bpm | ||
| No. | 3527 | 33,410 |
| Median (25th, 75th percentiles) | 74.0 (64.0, 85.0) | 72.0 (63.0, 84.0) |
| Diastolic BP, mmHg | ||
| No. | 3544 | 33,476 |
| Median (25th, 75th percentiles) | 77.0 (68.0, 86.0) | 78.0 (68.0, 87.0) |
| Systolic BP, mmHg | ||
| No. | 3547 | 33,502 |
| Median (25th, 75th percentiles) | 131.0 (120.0, 150.0) | 135.0 (120.0, 150.0) |
| Hypertension | 2047/3550 (57.7) | 20,734/33,548 (61.8) |
| Killip class, n (%) | ||
| Presentation | 3190 (100) | 29,658 (100) |
| I | 2941 (92.2) | 26,543 (89.5) |
| II | 202 (6.3) | 2584 (8.7) |
| III | 37 (1.2) | 417 (1.4) |
| IV | 10 (0.3) | 114 (0.4) |
| Creatinine at enrollment, mg/dl | ||
| No. | 3500 | 32,990 |
| Median (25th, 75th percentiles) | 1.0 (0.8, 1.1) | 1.0 (0.9, 1.2) |
| Creatinine clearance | ||
| No. | 3497 | 32,978 |
| Median (25th, 75th percentiles) | 80.2 (62.2, 103.8) | 76.2 (58.2, 97.6) |
| Qualifying event | ||
| Elevated cardiac markers | 1442/3533 (40.8) | 21,174/33,496 (63.2) |
| ECG changesa | 1541/3524 (43.7) | 18,350/33,388 (55.0) |
| GRACE risk (in-hospital death) | ||
| No. | 3550 | 33,551 |
| Median (25th, 75th percentiles) | 116.1 (95.7, 136.3) | 129.0 (110.6, 147.9) |
| GRACE risk (in-hospital death/MI) | ||
| No. | 3550 | 33,551 |
| Median (25th, 75th percentiles) | 139.0 (92.5, 165.9) | 159.1 (132.3, 199.1) |
Values are presented as n/total (%) unless otherwise noted.
BP: blood pressure; CAD: coronary artery disease; CABG: coronary artery bypass graft; CHF: congestive heart failure; ECG: electrocardiogram; GRACE: Global Registry for Acute Coronary Events; MI: myocardial infarction; PCI: percutaneous coronary intervention; PVD: peripheral vascular disease.
a
ECG changes = transient or persistent ST-segment depression of more than 0.5 mm; persistent, definite T-wave inversion of more than 1 mm; transient ST-segment elevation of more than 0.5 mm lasting less than 20 minutes.