Table 4.
Recurrent Small Overlapping Regions of Amplification*
| Chrom | Start | End | Size (Kb) |
Frequency (%) |
Genes | |
|---|---|---|---|---|---|---|
| HGD | EAC | |||||
| 3q26 | 173230050 | 186580274 | 13350 | 15.0 | 20.5 | PIK3CA & 93 genes |
| 5p13.2-p12 | 36348269 | 44184542 | 7836 | 0.0 | 20.0 | 53 genes |
| 6p21.33 | 30559883 | 31040288 | 480 | 0.0 | 16.7 | 24 genes |
| 6p21.1 | 41746737 | 44753714 | 3007 | 0.0 | 16.7 | VEGF & 69 genes |
| 7p22.2 | 795019 | 2280133 | 1485 | 0.0 | 25.6 | 25 genes |
| 7p11.2 | 54471518 | 56699692 | 2228 | 0.0 | 25.6 | EGFR & 33 |
| 7q21.2-q21.3 | 92102346 | 92744573 | 642 | 0.0 | 30.8 | CDK6 & 4 |
| 8p23.1 | 11194870 | 11897260 | 702 | 15.0 | 31.7 | CTSB & 15 |
| 8q24.21 | 127660810 | 129220171 | 1559 | 5.0 | 36.6 | MYC & 4 |
| 11q13.2-q13.3 | 69152144 | 69957414 | 805 | 0.0 | 16.7 | CCND1 & 10 |
| 12p12.1 | 25029283 | 25546789 | 518 | 5.0 | 19.5 | KRAS & 6 |
| 12q14.3 | 65978417 | 67060279 | 1082 | 5.0 | 19.5 | MDM1 & 8 |
| 13q14.3-q21.32 | 53356272 | 65178858 | 11823 | 10.0 | 22.5 | 30 genes |
| 17q21.2 | 36045007 | 36600822 | 556 | 10.0 | 19.5 | 38 genes |
| 18q11.2 | 17931784 | 18382880 | 451 | 15.0 | 17.5 | CTAGE1 & 3 |
| 20q13.2 | 50951694 | 51913648 | 962 | 0.0 | 28.6 | ZNF217 & 3 |
*
Only include regions with frequency>15% in EAC.