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. 2014 Jan 27;192(5):2195–2201. doi: 10.4049/jimmunol.1302082

FIGURE 4.

FIGURE 4.

Induction of CD86 by IL-21 is dependent on PI3K p110δ. (A) BALB/c CD19+ B cells (1 × 106) were cultured for 16 h alone or in the presence of 200 ng/ml IL-21 or 10 ng/ml IL-4. Where indicated, cultures also contained 10 μM LY-294002. Histograms show CD86 expression for gated CD19+ B cells. (B) BALB/c CD19+ B cells (1 × 106) were cultured for 16 h alone or in the presence of 200 ng/ml IL-21 or 10 ng/ml IL-4. Cells expressed the wild-type or mutant isoforms of PI3K P110δ as indicated. Histograms show CD86 expression for gated CD19+ B cells. Data are representative of three independent experiments.