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. Author manuscript; available in PMC: 2014 Dec 31.
Published in final edited form as: Biochemistry. 2013 Dec 17;52(52):9413–9425. doi: 10.1021/bi4010304

Figure 8.

Figure 8

Model of Fe trafficking in yeast cells. Fe from the medium enters via high-affinity (RHI) and low-affinity (RLO) pathways. RLO is unregulated while RHI is regulated by the concentration of cytosolic Fe (FeC), indicated by the dashed lines. FeC moves into the mitochondria and vacuoles, forming mitochondrial (FeM) and vacuolar (FeV) forms. The import of FeC into the mitochondria is regulated by the concentration of FeM. In version C, FeIII nanoparticles (FeP) were assumed to form in cytosol whereas in version V, they were assumed to form in vacuoles. Rate-constants and other parameters are listed in Table 1.