Table 1.
Functional side-chain correlations in GLUT1 concluded from positional homology of corresponding residues in XylE, GlcPSe, FucP, and LacY
| Function | GLUT1 | XylE | GlcPSe | FucP | LacY |
| Substrate ligand | F26 (Y32*) | F24 | N23 | N42 | H322 |
| Q161 | Q168 | Q137 | Q159 | E269 | |
| I168 | Q175 | I144 | N162 | N272 | |
| Q282 | Q288 | Q250 | — | F20 | |
| Q283 | Q299 | Q251 | — | — | |
| N288 | N294 | N256 | Y365 | — | |
| W388 (A396*) | W392 | W357 | Q274 | E126 | |
| N411 (H419*) | Q415 | N381 | R312 | R144 | |
| W412 | W416 | N381 | F308 | W151 | |
| H+ site | N29 (D79†) | D27 | D22 | D46 | E325 |
| Structural | G31 | T28 | N23 | P50 | P327 |
| G75/G76 | G67/C68 | G54/A55 | G73/– | A361/M362 | |
| G79/G134 | G71/G141 | G58/G110 | E135/Y74 | D237/K358 | |
| S80 | G72 | A59 | I79 | S366 | |
| G84/P401 | G76/G405 | G63/G370 | G402/G64 | G370/G159 | |
| G286/S414 | G292/A418 | G254/T384 | A359/C307 | G24/C154 | |
| S294 | P301 | S262 | P366 | P31 | |
| G384 (S392*) | G388 | G353 | G272 | G121 | |
| P385 | P389 | P354 | A276 | P123 | |
| Salt-bridged | D329/R400 | D337/R404 | D299/- | D406/R283 | D68/K131 |
| R126/–/N29 | R133/E206/D27 | R102/–/D22 | Y101/Y212/D45‡ | K319/D240/R302 |
An em dash (—) means homologous residue not found.
*
GLUT5.
†
GLUT13.
‡
Polar interaction.