Fig. 4.

Treatment of glucose-intolerant prediabetic NOD mice with mAb287 delays progression to clinical diabetes. (A) Groups of 12-wk-old female NOD mice were monitored for glucose intolerance (random blood glucose > 170 mg/mL) then treated weekly with 0.5 mg of mouse IgG1 (n = 7; blue diamonds), or 0.5mg of mAb287 (n = 7; red triangles), until the animals reached 25 wk of age. Diabetes was diagnosed as described in Materials and Methods. (B) Weekly random blood glucose levels of individual mice receiving mAb287 (Upper) or mouse IgG1 (Lower) of mice in A are shown.