Fig. 3.

Acute expression of mutant LRRK2 in adult mouse brain results in diminished staining of TGN markers in vivo. (A) Mouse striatum sections from animals 2 wk after injection with lentiviral vectors expressing either (Left) eGFP or (Right) G2019S mutant eGFP-LRRK2 stained for GFP (green), GLG1 (red), and TOPRO3 (blue in Bottom). (B) Counting of cells with minimal GLG1 staining in animals transduced with the vectors, with untransduced cells in the same sections also counted as controls. Error bars show SEM. ***P < 0.001 (Tukey posthoc test from one-way ANOVA compared with eGFP control).