Figure 3. Regulatory role of Notch signaling for myocardial regeneration. A, Notch signaling amplifies EPC differentiation into cardiomyocytes through Jagged 1, NICD and Wnts. B, MSCs enhance cardiomyocyte proliferative capacity through Jagged 1 and NICD. C, Notch signaling promotes the differentiation of CPCs into cardiomyocytes through Jagged 1, NICD, RBP-Jκ, and Nkx2.5. D, Notch signaling expands the proportion of CSCs differentiating into cardiomyocytes through Jagged 1, NICD, and Nkx2.5. E, Notch 1 signaling stimulates proliferation of immature cardiomyocytes through Jagged 1, NICD, and cyclin D1. F, Notch signaling activates cell cycle reentry of quiescent cardiomyocytes through NICD, RBP-Jκ, and cyclin D1. EPCs: endothelial progenitor cells; NICD: Notch intracellular domain; Wnts: Wnt signaling; MSCs: mesenchymal stromal cells; CPCs: cardiac progenitor cells; RBP-Jκ: recombination signal binding protein for immunoglobulin Jκ region; Nkx2.5: NK2 homeobox 5; CSCs: cardiac stem cells.