Table 3.
Frequencies of MTHFR C677T polymorphisms in childhood ALL patients and controls
| MTHFR C677T | Patient no. (%) | Control no. (%) | χ 2 | P | OR (95%CI) |
|---|---|---|---|---|---|
|
Genotype |
|
|
|
|
|
| CC |
28 (28.6) |
29 (31.2) |
|
- |
1.00# |
| CT |
44 (44.9) |
49 (52.7) |
0.046 |
0.829 |
0.930 (0.481 - 1.799) |
| TT |
26 (26.5) |
15 (16.1) |
1.969 |
0.161 |
1.795 (0.790 - 4.079) |
| CT + TT |
70 (71.4) |
64 (68.8) |
0.155 |
0.693 |
1.133 (0.609 - 2.106) |
|
Allele |
|
|
|
|
|
| C |
100 (51.0) |
107 (57.5) |
|
- |
1.00# |
| T | 96 (49.0) | 79 (42.5) | 1.627 | 0.202 | 1.300 (0.868 - 1.947) |
#As reference group; OR, crude odds ratio; —, not applicable; CI, confidence interval. CC, CT and TT overall distribution test, χ2test = 3.109, P = 0.211.