Table 4.
Frequencies of MTHFR A1298C polymorphisms in childhood ALL patients and controls
| MTHFR A1298C | Patient no. (%) | Control no. (%) | χ 2 * | P | OR (95%CI) |
|---|---|---|---|---|---|
|
Genotype |
|
|
|
|
|
| AA |
54 (55.1) |
67 (72.0) |
|
- |
1.00# |
| AC |
42 (42.9) |
25 (26.9) |
5.628 |
0.018 |
2.084 (1.131 - 3.841) |
| CC |
2 (2.0) |
1 (1.1) |
0.574 |
0.449 |
2.481 (0.219 - 28.104) |
| AC + CC |
44 (44.9) |
26 (28.0) |
5.898 |
0.015 |
2.100 (1.149 - 3.837) |
|
Allele |
|
|
|
|
|
| A |
150(76.5) |
159 (85.5) |
|
- |
1.00# |
| C | 46(23.5) | 27 (14.5) | 4.949 | 0.026 | 1.806 (1.068 - 3.053) |
*Corrected chi-square test; #as reference group; OR, crude odds ratio; —, not applicable; CI, confidence interval. AA, AC and CC overall distribution test, χ2test = 5.917, P = 0.05.